99 articles - From Friday Apr 25 2025 to Friday May 02 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gut |
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British Society of Gastroenterology guidelines on colorectal surveillance in inflammatory bowel disease. Core areas include: risk of colorectal cancer, IBD-related post-colonoscopy colorectal cancer; service organisation and supporting patient concordance; starting and stopping surveillance, who should or should not receive surveillance; risk stratification, including web-based multivariate risk calculation of surveillance intervals; colonoscopic modalities, bowel preparation, biomarkers and artificial intelligence aided detection; chemoprevention; the role of non-conventional dysplasia, serrated lesions and non-targeted biopsies; management of dysplasia, both endoscopic and surgical, and the structure and role of the multidisciplinary team in IBD dysplasia management; training in IBD colonoscopic surveillance, sustainability (green endoscopy), cost-effectiveness and patient experience. Sixteen research priorities are suggested. |
meta-analyses and systematic reviews
| Am J Gastroenterol |
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Gastrointestinal and Extraintestinal Symptoms among Celiac Disease Patients Undergoing a Dose Specified Gluten Challenge: a Systematic Review and Meta-Analysis. GC commonly induces gastrointestinal symptoms in CeD patients, with abdominal pain, bloating and nausea being most frequent. Standardized challenge protocols are needed to advance therapeutic research while minimizing symptom burden. |
| Endoscopy |
Optimal timing for lumen-apposing metal stent removal following endoscopic ultrasound-guided drainage of pancreatic fluid collections: a systematic review and meta-analysis. The results of this meta-analysis showed no difference in the incidence of AEs between early and late removal of LAMSs in the presence of moderate heterogeneity across studies. Removal within 4 weeks is not warranted, and it may instead be planned on a clinical case-by-case basis according on the patient's condition. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Alcohol-Attributable Cancer: Update From the Global Burden of Disease 2021 Study. From 2000 to 2021, although the ASDR from alcohol-attributable cancer declined, the total number of deaths continued to rise. This trend was accompanied by variations across sociodemographic groups and cancer types, particularly gastrointestinal cancers. Urgent efforts are needed both globally and at regional levels to address the burden of alcohol-attributable cancers. |
Association Between Volume, Intensity and Rhythm of Physical Activity Measured by Accelerometer and Risk of All-Cause and Cause-Specific Mortality in Individuals With MASLD. In individuals with MASLD, a higher volume and intensity of physical activity, as well as normal RAR supported lower all-cause and CVD mortality risk, which provided insights for management guidelines. |
Increased Risk of Cardiovascular Events After Coronary Interventions in Inflammatory Bowel Disease: A Nationwide Matched Cohort Study. Patients with IBD were at 37% higher risk of MACE after coronary intervention, indicating a need for intensified cardiovascular risk reduction in these high-risk individuals. |
| Am J Gastroenterol |
No Effect of Computer Aided Diagnosis on Colonoscopic Adenoma Detection in a Large Pragmatic Multicenter Randomized Study. In patients over the age of 50 with mixed colonoscopy indications, CADe did not increase the adenoma detection rate. Further studies should define the requirements for selective CADe use in routine clinical practice, particularly in relation to the examiner's baseline ADR. |
PARKINSON'S DISEASE AND THE GUT: A PRIMER FOR GASTROENTEROLOGISTS. These findings underscore the potential role of the gut as: (1) a site of early diagnosis and risk stratification for populations at high-risk for PD and (2) a potentially disease-modifying treatment approach. This review summarizes the current knowledge on the role of the gut-brain axis in PD pathogenesis, clinical disease course, prodromal GI symptoms and their underlying mechanisms, and stresses current knowledge gaps and future directions. |
Role of Endoscopy in Inflammatory Bowel Disease: What Every Gastroenterologist Should Know. A thorough understanding of the same can help us to assess disease activity and manage our patients. The purpose of this review is to provide an overview of the role of endoscopy in the management of IBD and to examine various anatomical variations in patients post-operatively. |
| Clin Gastroenterol Hepatol |
Characterization of Patients with Symptoms of Gastroparesis Having Frequent Emergency Department Visits and Hospitalizations. Our study of patients with symptoms of Gp revealed a sizeable subset have had Gp-related ED visits and hospitalizations over the past year. Several factors related to etiology, GE delay, GI symptom severity, depression severity, race, and lower income were associated with ED visits and hospitalizations. |
| Endosc Int Open |
Effect of gastroenterology resident use of a social network workgroup on skills in characterizing colorectal neoplasia: Prospective study. Gastroenterology resident 1-year use of a social network workgroup does not improve their skills in characterizing colorectal neoplasia. Further intensive training is needed to improve the characterization level of gastroenterology residents. |
Novel endoscopic gastric purse-string suture device for weight management in a porcine model (with video). We assessed its feasibility and efficacy in a porcine model in terms of histological, physiological, and metabolic outcomes. The results suggest that EGPSS offers a viable option for metabolic control. |
Sealed endoscopic full-thickness resection with sentinel node navigation for early gastric cancer without endoscopic submucosal dissection indication. This study suggests that appropriate case selection for sentinel lymph node biopsy could allow for oncologically safe and individualized minimally invasive surgery for early gastric cancer that is ineligible for endoscopic submucosal dissection. |
| Endoscopy |
Trends over time and inter-hospital variation in the primary treatment approach for T1 colon carcinomas in the Netherlands. No significant differences in RS or OS were found between high- vs low attitude centers (5-year RS 99.0% vs 97.7%, RER 0.97, 95%CI 0.51-1.84 and OS 87.9% vs 86.4%, HRadj 0.95, 95%CI 0.81-1.11), nor between patients treated after vs before 2018 (5-year RS 98.7% vs 98.7%, RER 0.82, 95%CI 0.46-1.46 and OS 86.7% vs 88.0%, HRadj 0.98, 95%CI 0.85-1.13). CONCLUSIONS While inter-hospital variation exists, LR of T1 CC is increasingly preferred in the Netherlands, leading to a reduction in the number of surgeries without a change in RS or OS. |
| Gastroenterology |
Artificial Intelligence in Biliopancreatic Disorders: Applications in Cross-Imaging and Endoscopy. Promising applications in biliopancreatic endoscopy include the detection of biliary stenosis, classification of dysplastic precursor lesions, and assessment of pancreatic abnormalities. This review aims to capture the current state of artificial intelligence application in biliopancreatic disorders, summarizing the results of early studies, and paving the path for future directions. |
| Gastrointest Endosc |
Development of an Electronic Patient Safety Surveillance Model to Efficiently Identify Potential Adverse Events for Gastrointestinal Endoscopies. This electronic AE surveillance model can efficiently identify outpatient GI endoscopy cases with a high likelihood of patient harm to complement existing strategies for AE monitoring. Additionally, this methodology demonstrates flexibility to either maximize AE identification or minimize chart review burden by changing the "AE flag" threshold. Such tools should enhance quality improvement opportunities, patient safety, and understanding of AEs in routine GI endoscopy. |
Endoscopic biliary drainage in patients with surgically-altered anatomy: the street multicenter study. BD in patients with SAA is still associated with suboptimal chance of success in al the different types of reconstruction. The increasing use of interventional EUS procedures in the last years significantly improved outcomes in patients with SAA treated with these techniques. |
Endoscopic mucosal resection versus surgery for colon adenomas and early-stage cancers: a comparative effectiveness study. Among patients with eligible colonic lesions, all-cause mortality and healthcare utilization was significantly lower in those treated with EMR, in a community-based practice. |
Indefinite for Dysplasia in Barrett's Esophagus Carries Substantial Risk for Prevalent and Incident Neoplasia: Updated Outcomes and Long-Term Follow-up. IND carries substantial risk for progression to neoplasia including HGD/EAC, especially in the first year after diagnosis. Incident HGD/EAC risk approximates that published for LGD. |
Long-term (3-year) Composite Gastroesophageal Reflux outcomes of Peroral Endoscopic Myotomy with or without concomitant Endoscopic Fundoplication in matched cohorts of achalasia. In a retrospective matched cohort, GER was significantly less frequent after POEM+F than only POEM, and wrap integrity was maintained in three-fourths patients at 3-year follow-up. |
Prophylactic Clipping versus No Clipping Following Endoscopic Mucosal Resection of Large Non-Pedunculated Colon Polyps: A Cost-Effectiveness Analysis. At a WTP threshold of 100,000 USD per QALY, PC is cost-saving for proximal LNPCPs, cost-effective for very large (≥40 mm) LNPCPs, and cost-saving for patients with LNPCPs on antithrombotics. Reducing clip costs (≤$217) and optimizing usage (≤4 clips) further improve economic viability of PC. |
| Gut |
BSG/ACPGBI guidance on the management of colorectal polyps in patients with limited life expectancy. This guidance provides a framework to facilitate more objective and informed decision-making, from which an individualised plan can be developed between the patient and their clinician. |
DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis. Elevated DUOX2 signalling contributes to epithelial barrier dysfunction, microbiome alterations and subclinical inflammation. Butyrate and HDAC inhibitors reversed these effects, indicating that DUOX2 may be a therapeutic target in IBD. |
Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD. This integrated multimodel approach provides a framework for systematically assessing the molecular landscape of intestinal inflammation. Our findings reveal conserved inflammatory circuits, refine model selection, offering a valuable resource for the IBD research community. |
Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial. Parecoxib sequential with imrecoxib was effective and well tolerated in reducing the occurrence and duration of SAP and local complications through suppression of systemic inflammatory response, leading to decreased morbidity. |
| Hepatology |
AASLD Practice Statement on the evaluation and management of metabolic dysfunction-associated steatotic liver disease in children. It also discusses the implications of the 2023 nomenclature revision, which emphasizes evaluating both hepatic steatosis and cardiometabolic risk factors. With increasing recognition of MASLD's cardiometabolic burden and long-term health consequences, this practice statement provides a structured framework to advance clinical care and research in pediatric MASLD. |
Alcohol-induced disruption of hepatic m6A modification exacerbates alcohol-associated steatohepatitis by impairing liver immune microenvironment homeostasis. Collectively, our results demonstrate that alcohol consumption disrupts the homeostasis of hepatic immune microenvironment in ASH through impairment of METTL3-dependent m6A RNA modification. Targeting METTL3 to preserve its enzymatic activity and stability could represent a novel therapeutic avenue for ASH intervention. |
Altered blood-brain barrier permeability is associated with abnormal distant connectivity and regional homogeneity in covert hepatic encephalopathy - a cross sectional study. There was a strong association between disrupted blood-brain barrier (BBB) integrity and attenuated functional connectivity, with reductions in functional connectivity within the DMN and Frontoparietal Network (FPN), circuits closely linked to executive control. This attenuation was evident both in local regional and in distant connectivity within these networks. |
Organ damage proteomic signature identifies patients with MASLD at-risk of systemic complications. Our study provides a framework for potential mechanisms associated with systemic diseases that facilitates holistic management by stratifying patients with MASLD into subclasses at-risk of extrahepatic manifestations. |
| J Neurogastroenterol Motil |
Irritable Bowel Syndrome-like Symptoms in Patients With Ulcerative Colitis in Remission as Compared to Irritable Bowel Syndrome: Symptom Severity and Inflammatory Markers. One-third and one-tenth of UC-R patients met Rome III and IV IBS criteria, respectively. UC-IBS had lower IBS-SSS and higher fecal calprotectin than IBS. Psychological comorbidities were worse in IBS, least in UC-R without IBS, suggesting more peripheral inflammation and less central involvement in UC-IBS. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
Systemic treatment in patients with hepatocellular carcinoma and advanced liver dysfunction. In this recent advances article, we discuss how the clinical course of cirrhosis can affect eligibility to treatment in the modern era of systemic therapy for HCC, elaborate on strategies to improve liver function in HCC patients by targeting cirrhosis-related and tumour-related factors and summarise the current literature on systemic therapy in HCC patients with Child-Pugh class B. Based on this information, we finally propose a clinical algorithm on how to systematically approach patients with HCC and advanced liver dysfunction in clinical practice. |
Translational strategies for oral delivery of faecal microbiota transplantation. We postulate that continued innovation in OralFMT and LBPs via a multidisciplinary approach can further increase therapeutic efficacy and scalability by enabling disease site targeting, co-delivery of therapeutic compounds and overcoming colonisation resistance. Realising these goals positions OralFMT as a cornerstone of personalised care across a range of diseases rooted in microbiome health. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Endoscopy |
| Gastroenterology |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Endosc Int Open |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| J Hepatol |